Thursday, May 31 - Saturday, June 2, 2001
Conference 1A
| Semi-Finals May 31 8:30 am and 11:00 am |
Final June 2 8:00 am |
A State Champion |
| Region Champion Collinsville (21-6) |
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| vs | Joaquin 2-0 (9) vs |
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| Region Champion Joaquin (16-11) |
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| A State Champion: Shiner 10-4 |
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| Region Champion Shiner (20-4) |
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| vs | Shiner 2-1 (11) | |
| Region Champion Brock (21-8) |
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Conference 2A
| Semi-Finals May 31 2:00 pm and 4:30 pm |
Final June 2 11:00 am |
2A State Champion |
| Region Champion Archer City (21-3) |
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| vs | Archer City 2-0 vs |
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| Region Champion Rogers (22-4) |
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| 2A State Champion: Archer City 2-1 |
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| Region Champion Weimar (33-2) |
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| vs | Weimar 4-0 | |
| Region Champion De Kalb (19-10) |
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Conference 3A
| Semi-Finals May 31, 7:30 pm June 1, 8:30 am |
Final June 2 2:00 pm |
3A State Champion |
| Region Champion Sanger (23-2-1) |
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| vs | Sanger 5-0 vs |
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| Region Champion Sinton (26-4-3) |
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| 3A State Champion: Sanger 2-0 (17) |
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| Region Champion Splendora (23-5) |
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| vs | Midland Greenwood 1-0 (9) | |
| Region Champion Midland Greenwood (32-8) |
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Conference 4A
| Semi-Finals June 1 11:30 am and 2:00 pm |
Final June 2 5:00 pm |
4A State Champion |
| Region Champion Port Neches-Groves (33-6) |
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| vs | Hallsville 5-1 vs |
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| Region Champion Hallsville (32-7) |
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| 4A State Champion: Spring Branch Smithson Valley 5-1 |
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| Region Champion Spring Branch Smithson Valley (29-5) |
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| vs | Spring Brach Smithson Valley 4-3 | |
| Region Champion Wichita Falls Rider (25-5) |
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Conference 5A
| Semi-Finals June 1 5:00 pm and 8:00 pm |
Final June 2 8:00 pm |
5A State Champion |
| Region Champion Coppell (27-1) |
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| vs | Coppell 3-0 vs |
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| Region Champion Garland Lakeview Centennial (27-5-1) |
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| 5A State Champion: Coppell 1-0 (9) |
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Region Champion Katy Taylor (30-3) |
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| vs | Katy Taylor 6-0 |
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| Region Champion San Antonio Holmes (31-4) |
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UIL Softball All-Tournament Teams and Most Valuable Players
as selected by the media
| Conference 1A | |||
| Pitcher | Lindsey Michalec | Sr. | Shiner |
| Catcher | Heather Stratman | Sr. | Shiner |
| 1B | Amy Downey | Jr. | Shiner |
| 2B | Lindsey Maxey | Sr. | Shiner |
| 3B | Melissa Boedeker | So. | Shiner |
| SS | Cherise Kasper | So. | Shiner |
| OF | Kimberly Cook | Jr. | Joaquin |
| OF | Hailey Michalec | Fr. | Shiner |
| OF | Chelsea Malina | Fr. | Shiner |
| Utility | Ashley Jones | Sr. | Joaquin |
| Conference 2A | |||
| Pitcher | Kayla Jones | Sr. | Archer City |
| Catcher | Amanda Rosenauer | Fr. | Weimar |
| 1B | Renea Shelton | Sr. | Archer City |
| 2B | Colby Delgado | Jr. | Weimar |
| 3B | Jennifer Oncken | So. | Weimar |
| SS | Courtney Veal | Sr. | Archer City |
| OF | Reagan Kasparek | Fr. | Weimar |
| OF | Anna Campbell | Sr. | Archer City |
| OF | Danielle Goodwin | So. | Weimar |
| Utility | Megan Srubar | Fr. | Weimar |
| Conference 3A | |||
| Pitcher | Amber Woods | Sr. | Sanger |
| Catcher | Alexis Vigil | So. | Midland Greenwood |
| 1B | Miceala Minner | So. | Sanger |
| 2B | Ashley Awalt | Jr. | Midland Greenwood |
| 3B | Audrey Kelly | Sr. | Sanger |
| SS | Amy Hughes | Sr. | Sanger |
| OF | Holly Miller | Sr. | Sanger |
| OF | Jessica Hudson | Sr. | Sanger |
| OF | Stephanie Adams | So. | Midland Greenwood |
| Utility | Erin Smith | Jr. | Midland Greenwood |
| Conference 4A | |||
| Pitcher | Jill Garro | Jr. | Smithson Valley |
| Catcher | Jenilee Skender | Sr. | Hallsville |
| 1B | Loren Munoz | Jr. | Smithson Valley |
| 2B | Allison Strickland | Jr. | Hallsville |
| 3B | Stephanie Beason | So. | Hallsville |
| SS | Harmony Schwethelm | Jr. | Smithson Valley |
| OF | Kristy Knudsen | Sr. | Smithson Valley |
| OF | Heather Polhamus | Sr. | Smithson Valley |
| OF | Sara Suggs | Jr. | Hallsville |
| Utility | Loni Rasberry | Sr. | Hallsville |
| Conference 5A | |||
| Pitcher | Nicole Denes | Jr. | Coppell |
| Catcher | Pam Brown | Jr. | Coppell |
| 1B | Vanessa Aldana | Sr. | San Antonio Holmes |
| 2B | Callye Williams | Jr. | Katy Taylor |
| 3B | Courtney Anderson | So. | Coppell |
| SS | Kelly Dunn | Sr. | Katy Taylor |
| OF | Tina Boutelle | Jr. | Katy Taylor |
| OF | Raquel Spencer | Jr. | Katy Taylor |
| OF | Kelly Rhyme | Sr. | Coppell |
| Utility | Cristin Vitel | Sr. | Katy Taylor |